SYNTHESIS OF 5-(AROYLAMINO)-2-METHYL-2H-1,2,4-THIADIAZOL-3-ONES BY OXIDATIVE CYCLIZATION OF 1-AROYL-5-METHYL-2-THIOBIURETS

被引：27

作者：

CHO, NS ^{[1
]}

SHON, HI ^{[1
]}

PARKANYI, C ^{[1
]}

机构：

[1] FLORIDA ATLANTIC UNIV,DEPT CHEM,BOCA RATON,FL 33431

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 07期

关键词：

D O I：

10.1002/jhet.5570280701

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Aroylamino-2-methyl-2H-1,2,4,thiadiazol-3-ones 3 have been synthesized by oxidative cyclization of 1-aroyl-5-methyl-2-thiobiurets 2 with hydrogen peroxide in an alkaline solution. The needed 1-aroyl-5-methyl-2-thiobiurets 2 have been obtained through the addition of methylurea to the corresponding aroyl isothiocyanates.

引用

页码：1645 / 1649

页数：5