IMMUNOCYTOCHEMICAL LOCALIZATION OF SYNAPTIC VESICLE-SPECIFIC PROTEIN IN LEWY BODY-CONTAINING NEURONS IN PARKINSONS-DISEASE

被引:42
作者
WAKABAYASHI, K [1 ]
TAKAHASHI, H [1 ]
OBATA, K [1 ]
IKUTA, F [1 ]
机构
[1] NATL INST PHYSIOL SCI,NEUROCHEM LAB,OKAZAKI,AICHI 444,JAPAN
关键词
PARKINSONS DISEASE; LEWY BODY; IMMUNOCYTOCHEMISTRY; SYNAPTIC VESICLE-SPECIFIC 38-KDA PROTEIN; MICROTUBULE-ASSOCIATED PROTEIN-2;
D O I
10.1016/0304-3940(92)90923-U
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We carried out an immunocytochemical examination of the brainstem and sympathetic ganglia of 5 autopsied patients with Parkinson's disease, using monoclonal antibodies against microtubule-associated protein 2 (MAP2) and synaptic vesicle-specific 38 kDa protein (SVP38). Lewy bodies (LBs) in the nerve cell somata were often immunoreactive for MAP2. Immunoreactivity of SVP38 in the somata of nerve cells was rarely demonstrated in the peripheral portion of the LBs. On the other hand, SVP38-immunoreactive (IR) LB-containing nerve cell processes were frequently found in the brainstem and sympathetic ganglia, considerably outnumbering MAP2-IR LB-containing nerve cell processes. These findings suggested that SVP38 is stored in LB-containing nerve cell processes and indicate that the majority of these processes are axons.
引用
收藏
页码:237 / 240
页数:4
相关论文
共 21 条
[1]   AN ANTIGENIC PROFILE OF LEWY BODIES - IMMUNOCYTOCHEMICAL INDICATION FOR PROTEIN-PHOSPHORYLATION AND UBIQUITINATION [J].
BANCHER, C ;
LASSMANN, H ;
BUDKA, H ;
JELLINGER, K ;
GRUNDKEIQBAL, I ;
IQBAL, K ;
WICHE, G ;
SEITELBERGER, F ;
WISNIEWSKI, HM .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1989, 48 (01) :81-93
[3]   PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONS DISEASE [J].
DUFFY, PE ;
TENNYSON, VM .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1965, 24 (03) :398-+
[4]   REACTION OF LEWY BODIES WITH ANTIBODIES TO PHOSPHORYLATED AND NONPHOSPHORYLATED NEUROFILAMENTS [J].
FORNO, LS ;
STERNBERGER, LA ;
STERNBERGER, NH ;
STREFLING, AM ;
SWANSON, K ;
ENG, LF .
NEUROSCIENCE LETTERS, 1986, 64 (03) :253-258
[5]  
FORNO LS, 1976, ACTA NEUROPATHOL, V34, P183, DOI 10.1007/BF00688674
[6]  
FORNO LS, 1986, ADV NEUROL, V45, P35
[7]   LEWY BODIES CONTAIN EPITOPES BOTH SHARED AND DISTINCT FROM ALZHEIMER NEUROFIBRILLARY TANGLES [J].
GALLOWAY, PG ;
GRUNDKEIQBAL, I ;
IQBAL, K ;
PERRY, G .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1988, 47 (06) :654-663
[8]   NEUROPATHOLOGY OF IMMUNOHISTOCHEMICALLY IDENTIFIED BRAIN-STEM NEURONS IN PARKINSONS-DISEASE [J].
HALLIDAY, GM ;
LI, YW ;
BLUMBERGS, PC ;
JOH, TH ;
COTTON, RGH ;
HOWE, PRC ;
BLESSING, WW ;
GEFFEN, LB .
ANNALS OF NEUROLOGY, 1990, 27 (04) :373-385
[9]   USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].
HSU, SM ;
RAINE, L ;
FANGER, H .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580
[10]   THE DISTRIBUTION OF LEWY BODIES IN THE CENTRAL AND AUTONOMIC NERVOUS SYSTEMS IN IDIOPATHIC PARALYSIS AGITANS [J].
JAGER, WAD ;
BETHLEM, J .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (04) :283-290