IMMUNOCYTOCHEMICAL LOCALIZATION OF SYNAPTIC VESICLE-SPECIFIC PROTEIN IN LEWY BODY-CONTAINING NEURONS IN PARKINSONS-DISEASE

被引：42

作者：

WAKABAYASHI, K ^{[1
]}

TAKAHASHI, H ^{[1
]}

OBATA, K ^{[1
]}

IKUTA, F ^{[1
]}

机构：

[1] NATL INST PHYSIOL SCI,NEUROCHEM LAB,OKAZAKI,AICHI 444,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 02期

关键词：

PARKINSONS DISEASE; LEWY BODY; IMMUNOCYTOCHEMISTRY; SYNAPTIC VESICLE-SPECIFIC 38-KDA PROTEIN; MICROTUBULE-ASSOCIATED PROTEIN-2;

D O I：

10.1016/0304-3940(92)90923-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We carried out an immunocytochemical examination of the brainstem and sympathetic ganglia of 5 autopsied patients with Parkinson's disease, using monoclonal antibodies against microtubule-associated protein 2 (MAP2) and synaptic vesicle-specific 38 kDa protein (SVP38). Lewy bodies (LBs) in the nerve cell somata were often immunoreactive for MAP2. Immunoreactivity of SVP38 in the somata of nerve cells was rarely demonstrated in the peripheral portion of the LBs. On the other hand, SVP38-immunoreactive (IR) LB-containing nerve cell processes were frequently found in the brainstem and sympathetic ganglia, considerably outnumbering MAP2-IR LB-containing nerve cell processes. These findings suggested that SVP38 is stored in LB-containing nerve cell processes and indicate that the majority of these processes are axons.

引用

页码：237 / 240

页数：4