CONVERSION OF CHIRAL AMINO-ACIDS TO ENANTIOMERICALLY PURE ALPHA-METHYLAMINES

被引:26
作者
DONNER, BG
机构
[1] Aging and Degenerative Diseases Research Division, Department 47B, Abbott Laboratories, Abbott Park
关键词
D O I
10.1016/0040-4039(95)00039-F
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Enantiomerically enriched alpha-methylamines are obtained in high yield by Raney nickel reduction of N-Boc-protected, amino acid-derived thioethers.
引用
收藏
页码:1223 / 1226
页数:4
相关论文
共 16 条
  • [1] DESIGN, SYNTHESIS, AND PHYSICOCHEMICAL PROPERTIES OF A NOVEL, CONFORMATIONALLY RESTRICTED 2,3-DIHYDRO-1,3,4-THIADIAZOLE-CONTAINING ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR WHICH IS PREFERENTIALLY ELIMINATED BY THE BILIARY ROUTE IN RATS
    BENNION, C
    BROWN, RC
    COOK, AR
    MANNERS, CN
    PAYLING, DW
    ROBINSON, DH
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 439 - 447
  • [2] SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF ENANTIOMERICALLY PURE 4-DEOXY-4-FLUOROMUSCARINES
    BRAVO, P
    RESNATI, G
    ANGELI, P
    FRIGERIO, M
    VIANI, F
    ARNONE, A
    MARUCCI, G
    CANTALAMESSA, F
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (17) : 3102 - 3110
  • [3] ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID, A VERSATILE REAGENT FOR DETERMINATION OF ENANTIOMERIC COMPOSITION OF ALCOHOLS AND AMINES
    DALE, JA
    DULL, DL
    MOSHER, HS
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (09) : 2543 - &
  • [4] THE SYNTHESIS OF ALPHA-BETA-UNSATURATED KETONES FROM BETA-SILYLENONES AND BETA-SILYLYNONES
    FLEMING, I
    PERRY, DA
    [J]. TETRAHEDRON, 1981, 37 (23) : 4027 - 4034
  • [5] N-ARALKYL SUBSTITUTION OF 2-AMINO-5,6 AND 6,7-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENES .1. CARDIAC AND PRESSOR-DEPRESSOR ACTIVITIES
    GORCZYNSKI, RJ
    ANDERSON, WG
    STOUT, DM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (07) : 835 - 839
  • [6] SYNTHESES AND PROPERTIES OF OPTICALLY-ACTIVE 2-SUBSTITUTED TAURINES
    HIGASHIURA, K
    MORINO, H
    MATSUURA, H
    TOYOMAKI, Y
    IENAGA, K
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (08): : 1479 - 1481
  • [7] STEREOCHEMISTRY AND REGIOCHEMISTRY OF HETEROATOM DIRECTED REACTIONS .5. THE 1ST PRACTICAL METHOD OF SELECTIVE HETEROATOM-DIRECTED CHLOROHYDROXYLATION
    LAI, JY
    WANG, FS
    GUO, GZ
    DAI, LX
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (25) : 6944 - 6946
  • [8] Larock R.C., 1989, COMPREHENSIVE ORGANI
  • [9] SYNTHESIS, ABSOLUTE-CONFIGURATION, STEREOSELECTIVITY, AND RECEPTOR SELECTIVITY OF (ALPHA-R,BETA-S)-ALPHA,BETA-DIMETHYLHISTAMINE, A NOVEL HIGHLY POTENT HISTAMINE H-3 RECEPTOR AGONIST
    LIPP, R
    ARRANG, JM
    GARBARG, M
    LUGER, P
    SCHWARTZ, JC
    SCHUNACK, W
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) : 4434 - 4441
  • [10] 2,3-DIHYDROBENZOFURAN ANALOGS OF HALLUCINOGENIC PHENETHYLAMINES
    NICHOLS, DE
    SNYDER, SE
    OBERLENDER, R
    JOHNSON, MP
    HUANG, XM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 276 - 281