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ANTIOXIDANT PROPERTIES OF DIAMINES AND POLYAMINES

被引：34
作者：
MATKOVICS, B
KECSKEMETI, V
VARGA, SI
NOVAK, Z
KERTESZ, Z
机构：
[1] ATTILA JOZSEF UNIV,BIOL ISOTOPE LAB,H-6701 SZEGED,HUNGARY
[2] SEMMELWEIS UNIV MED,DEPT PHARMACOL,H-1085 BUDAPEST 8,HUNGARY
[3] SZENT GYORGYI ALBERT MED SCH,SZEGED,HUNGARY
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1993年 / 104卷 / 03期
基金：
匈牙利科学研究基金会;
关键词：
D O I：
10.1016/0305-0491(93)90269-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. One diamine, putrescine and two polyamines, spermidine and spermine (PAs) of different concentrations, were processed through antioxidant systems in order to study their antioxidant effects. The systems investigated were as follows. 2. ''Oxidative stress'' was induced in RBCs to investigate filtration parameters, the effect of reduced glutathione (GSH) and the change in lipid peroxidation (LP) superoxide dismutase (SOD) activities. 3. Initiated LP-decreasing characteristics of the substances were studied in pig brain homogenate. 4. The LP-decreasing effect of these PAs were studied in guinea-pig heart tissue homogenate perfused with Tyrode solution, stimulated, and then perfused by the Langendorff method. 5. In all three tests, the antioxidant characteristics of PAs were unambiguously proved.
引用
收藏
页码：475 / 479
页数：5
相关论文
共 20 条
[1]   STABILIZATION OF ERYTHROCYTE-MEMBRANES BY POLYAMINES [J].
BALLAS, SK ;
MOHANDAS, N ;
MARTON, LJ ;
SHOHET, SB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (07) :1942-1946
[2]   PUTRESCINE REVERSES ACONITINE-INDUCED ARRHYTHMIA IN RATS [J].
BAZZANI, C ;
GENEDANI, S ;
TAGLIAVINI, S ;
BERTOLINI, A .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1989, 41 (09) :651-653
[3]   MOLECULAR-BASIS FOR CELLULAR EFFECTS OF NATURALLY-OCCURRING POLYAMINES [J].
BUEB, JL ;
MOUSLI, M ;
LANDRY, Y .
AGENTS AND ACTIONS, 1991, 33 (1-2) :84-87
[4]   POLYAMINES AND THE CALCIUM PARADOX IN RAT HEARTS [J].
BUSSELEN, P .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1991, 23 (03) :237-247
[5]   THE ROLE OF POLYAMINES IN BETA-ADRENERGIC STIMULATION OF CALCIUM INFLUX AND MEMBRANE-TRANSPORT IN RAT-HEART [J].
FAN, CC ;
KOENIG, H .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1988, 20 (09) :789-799
[6]   MODIFICATION OF THE CARDIAC TRANSMEMBRANE POTENTIALS AND CURRENTS BY POLYAMINES [J].
KECSKEMETI, V ;
KELEMEN, K ;
MARKO, R ;
SELMECI, L .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 142 (02) :297-303
[7]   SPERMINE - AN ANTIOXIDANT AND ANTIINFLAMMATORY AGENT [J].
LOVAAS, E ;
CARLIN, G .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 11 (05) :455-461
[8]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[9]   COMPARATIVE-STUDY OF SOME MORE IMPORTANT EXPERIMENTAL ANIMAL PEROXIDE METABOLISM ENZYMES [J].
MATKOVICS, B ;
NOVAK, R ;
HANH, HD ;
SZABO, L ;
VARGA, SI ;
ZALESNA, G .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1977, 56 (01) :31-34
[10]  
MISRA HP, 1972, J BIOL CHEM, V247, P3170
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