BIOTRANSFORMATION OF ORGANIC SULFIDES .7. FORMATION OF CHIRAL ISOTHIOCYANATO SULFOXIDES AND RELATED-COMPOUNDS BY MICROBIAL BIOTRANSFORMATION

被引：36

作者：

HOLLAND, HL

BROWN, FM

LARSEN, BG

ZABIC, M

机构：

[1] Department of Chemistry, Brock University, St. Catharines

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00200-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The fungi Helminthosporium species NRRL 4671 and Mortierella isabellina ATCC 42613 have been used for the biotransformation of a series of isothiocyanatoalkyl methyl sulfides and their synthetic precursors, omega-(methylthio)alkylphthalimides. H. species gave predominantly (S) sulfoxides in all cases; M. isabellina gave (R) isothiocyanatoalkyl methyl sulfoxides, but in the case of two omega(methylthio)alkylphthalimides substantial conversion of sulfoxide to sulfone resulted in the isolation of the former with predominant (S) configuration. A correction is made of the previously reported configurations of two biotransformation products (Tetrahedron: Asymmetry, 1994, 5, 1129).

引用

页码：1569 / 1574

页数：6

共 16 条

[1] STEREOCHEMICAL ANALYSIS OF SULFOXIDES OBTAINED BY DIVERTED DESATURATION [J].