Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: Preliminary report

被引：73

作者：

Fukuzako, H ^{[1
]}

Takeuchi, K ^{[1
]}

Hokazono, Y ^{[1
]}

Fukuzako, T ^{[1
]}

Yamada, K ^{[1
]}

Hashiguchi, T ^{[1
]}

Obo, Y ^{[1
]}

Ueyama, K ^{[1
]}

Takigawa, M ^{[1
]}

Fujimoto, T ^{[1
]}

机构：

[1] S JAPAN HLTH SCI CTR,MIYAZAKI,JAPAN

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1995年 / 61卷 / 04期

关键词：

frontal lobe; temporal lobe; medial; N-acetylaspartate;

D O I：

10.1016/0925-4927(95)02622-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Proton magnetic resonance spectroscopy (MRS) was performed in 30 medicated schizophrenic patients and 30 normal subjects. Two groups, each containing 15 schizophrenic patients and 15 age- and sex-matched normal subjects, received MRS examinations for different volumes of interest, either the frontal lobe or the medial temporal lobe. Schizophrenic patients showed a decrease in the ratios of N-acetylaspartate (NAA)/choline-containing compounds (Cho) and NAA/creatine-phosphocreatine (Cr). The patients also showed an increase in the ratio of Cho/Cr in the left medial temporal lobe but not in the left frontal lobe. The age at onset of illness correlated positively with the ratios of NAA/Cho and NAA/Cr in the medial temporal lobe. No significant correlation was observed between the ratios of NAA/Cho, NAA/Cr, or Cho/Cr in the left medial temporal and frontal lobes and clinical symptomatology as assessed by the Scale for the Assessment of Negative Symptoms and the Positive and Negative Syndrome Scale.

引用

页码：193 / 200

页数：8

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