FROM CADHERINS TO CATENINS - CYTOPLASMIC PROTEIN INTERACTIONS AND REGULATION OF CELL-ADHESION

被引：909

作者：

KEMLER, R

机构：

[1] R. Kemler is in the Max Planck Institut für Immunobiologie, W-7800 Freiburg

来源：

TRENDS IN GENETICS | 1993年 / 9卷 / 09期

关键词：

D O I：

10.1016/0168-9525(93)90250-L

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Classical cadherins are complexed via their cytoplasmic domains with alpha-, beta- and gamma-catenin. This complex formation links cadherins to the actin filament network and to other transmembrane and cytoplasmic proteins. Alpha-catenin is homologous to vinculin, and beta-catenin to the product of the Drosophila gene armadillo, while gamma-catenin seems to be identical to plakoglobin. Catenins are part of a higher order protein structure that is of crucial importance for the adhesive function of cadberins. A working model of the construction and regulation of this multiprotein interaction is proposed.

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页码：317 / 321

页数：5

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