SEROTONIN RECEPTORS - SUBTYPES, FUNCTIONAL-RESPONSES AND THERAPEUTIC RELEVANCE

被引：199

作者：

SAXENA, PR ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,CARDIOVASC RES INST COEUR,3000 DR ROTTERDAM,NETHERLANDS

来源：

PHARMACOLOGY & THERAPEUTICS | 1995年 / 66卷 / 02期

关键词：

ANXIETY; CARDIAC DISORDERS; CENTRAL NERVOUS SYSTEM DISEASES; DEPRESSION; GASTRIC MOTILITY DISORDERS; 5-HYDROXYTRYPTAMINE; 5-HYDROXYTRYPTAMINE RECEPTORS; HYPERTENSION; MIGRAINE; PAIN; SEROTONIN; VOMITING;

D O I：

10.1016/0163-7258(94)00005-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent, rapid progress in the molecular biology of serotonin (5-HT) receptors requires conceptual re-thinking with respect to receptor classification. Thus, based on operational criteria (agonist and antagonist rank order), as well as transduction mechanisms involved and the structure of the receptor protein, the Nomenclature Committee of the Serotonin Club has proposed the following classification and nomenclature: the main receptor types 5-HT1 to 5-HT4, recombinant receptors (e.g. 5-ht(5) to 5-ht(7)) and 'orphan' receptors. The aim of the present review is to discuss the events leading to this classification, the criteria for and functional responses mediated by various 5-HT receptors, as well as the therapeutic possibilities with 5-HT ligands.

引用

页码：339 / 368

页数：30

共 271 条

[1]

ADHAM N, 1992, MOL PHARMACOL, V41, P1

[2]

ADHAM N, 1994, IN PRESS BR J PHARM

[3]

ADHAM N, 1993, P NATL ACAD SCI USA, V89, P408

[4]

ALBERT PR, 1990, J BIOL CHEM, V265, P5825

[5]

ALHAIDER AA, 1991, J NEUROSCI, V11, P1881

[6]

AMLAIKY N, 1992, J BIOL CHEM, V267, P19761

[7] STRUCTURE FUNCTIONAL EXPRESSION AND SPATIAL-DISTRIBUTION OF A CLONED CDNA-ENCODING A RAT 5-HT1D-LIKE RECEPTOR [J].

BACH, AWJ ;

UNGER, L ;

SPRENGEL, R ;

MENGOD, G ;

PALACIOS, J ;

SEEBURG, PH ;

VOIGT, MM .

JOURNAL OF RECEPTOR RESEARCH, 1993, 13 (1-4) :479-502

[8]

BAKER R, 1994, Patent No. 581538

[9]

BARD JA, 1993, J BIOL CHEM, V268, P23422

[10] 5-HT RECEPTORS MEDIATING CONTRACTIONS OF THE ISOLATED HUMAN CORONARY-ARTERY [J].

BAX, WA ;

RENZENBRINK, GJ ;

VANHEUVENNOLSEN, D ;

THIJSSEN, EJM ;

BOS, E ;

SAXENA, PR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 239 (1-3) :203-210

← 1 2 3 4 5 6 7 8 9 10 →