SEROTONIN RECEPTORS - SUBTYPES, FUNCTIONAL-RESPONSES AND THERAPEUTIC RELEVANCE

被引：201

作者：

SAXENA, PR ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,CARDIOVASC RES INST COEUR,3000 DR ROTTERDAM,NETHERLANDS

来源：

PHARMACOLOGY & THERAPEUTICS | 1995年 / 66卷 / 02期

关键词：

ANXIETY; CARDIAC DISORDERS; CENTRAL NERVOUS SYSTEM DISEASES; DEPRESSION; GASTRIC MOTILITY DISORDERS; 5-HYDROXYTRYPTAMINE; 5-HYDROXYTRYPTAMINE RECEPTORS; HYPERTENSION; MIGRAINE; PAIN; SEROTONIN; VOMITING;

D O I：

10.1016/0163-7258(94)00005-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent, rapid progress in the molecular biology of serotonin (5-HT) receptors requires conceptual re-thinking with respect to receptor classification. Thus, based on operational criteria (agonist and antagonist rank order), as well as transduction mechanisms involved and the structure of the receptor protein, the Nomenclature Committee of the Serotonin Club has proposed the following classification and nomenclature: the main receptor types 5-HT1 to 5-HT4, recombinant receptors (e.g. 5-ht(5) to 5-ht(7)) and 'orphan' receptors. The aim of the present review is to discuss the events leading to this classification, the criteria for and functional responses mediated by various 5-HT receptors, as well as the therapeutic possibilities with 5-HT ligands.

引用

页码：339 / 368

页数：30

共 271 条

[61] PRESYNAPTIC INHIBITORY ACTION OF 5-HYDROXYTRYPTAMINE IN DOG ISOLATED SAPHENOUS-VEIN [J].

FENIUK, W ;

HUMPHREY, PPA ;

WATTS, AD .

BRITISH JOURNAL OF PHARMACOLOGY, 1979, 67 (02) :247-254

[62] 5-HT3 RECEPTOR ANTAGONISTS AND MIGRAINE THERAPY [J].

FERRARI, MD .

JOURNAL OF NEUROLOGY, 1991, 238 :S53-S56

[63] CLINICAL AND EXPERIMENTAL EFFECTS OF SUMATRIPTAN IN HUMANS [J].

FERRARI, MD ;

SAXENA, PR .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (04) :129-133

[64] EFFICACY OF ICS 205-930, A NOVEL 5-HYDROXYTRYPTAMINE3 (5-HT3) RECEPTOR ANTAGONIST, IN THE PREVENTION OF MIGRAINE ATTACKS - A COMPLEX ANSWER TO A SIMPLE QUESTION [J].

FERRARI, MD ;

WILKINSON, M ;

HIRT, D ;

LATASTE, X ;

NOTTER, M .

PAIN, 1991, 45 (03) :283-291

[65]

FILLION GMB, 1978, MOL PHARMACOL, V14, P50

[66] WAY100135 - A NOVEL, SELECTIVE ANTAGONIST AT PRESYNAPTIC AND POSTSYNAPTIC 5-HT(1A) RECEPTORS [J].

FLETCHER, A ;

BILL, DJ ;

BILL, SJ ;

CLIFFE, IA ;

DOVER, GM ;

FORSTER, EA ;

HASKINS, JT ;

JONES, D ;

MANSELL, HL ;

REILLY, Y .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 237 (2-3) :283-291

[67] CLONING AND FUNCTIONAL-CHARACTERIZATION OF THE RAT STOMACH FUNDUS SEROTONIN RECEPTOR [J].

FOGUET, M ;

HOYER, D ;

PARDO, LA ;

PAREKH, A ;

KLUXEN, FW ;

KALKMAN, HO ;

STUHMER, W ;

LUBBERT, H .

EMBO JOURNAL, 1992, 11 (09) :3481-3487

[68] STRUCTURE OF THE MOUSE 5-HT1C, 5-HT2 AND STOMACH FUNDUS SEROTONIN RECEPTOR GENES [J].

FOGUET, M ;

NGUYEN, H ;

LE, H ;

LUBBERT, H .

NEUROREPORT, 1992, 3 (04) :345-348

[69] N-(1-METHYL-5-INDOLYL)-N'-(3-PYRIDYL)UREA HYDROCHLORIDE - THE 1ST SELECTIVE 5-HT(1C) RECEPTOR ANTAGONIST [J].

FORBES, IT ;

KENNETT, GA ;

GADRE, A ;

HAM, P ;

HAYWARD, CJ ;

MARTIN, RT ;

THOMPSON, M ;

WOOD, MD ;

BAXTER, GS ;

GLEN, A ;

MURPHY, OE ;

STEWART, BA ;

BLACKBURN, TP .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (08) :1104-1107

[70] 5-HYDROXYTRYPTAMINE STIMULATES CYCLIC-AMP FORMATION IN THE TUNICA MUSCULARIS MUCOSAE OF THE RAT ESOPHAGUS VIA 5-HT(4) RECEPTORS [J].

FORD, APDW ;

BAXTER, GS ;

EGLEN, RM ;

CLARKE, DE .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 211 (01) :117-120

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