SELF-REPRODUCTION OF CHIRALITY - ASYMMETRIC-SYNTHESIS OF BETA-ALKYL-BETA-AMINO ACIDS FROM ENANTIOMERICALLY PURE DIHYDROPYRIMIDINONES

被引：20

作者：

CHU, KS ^{[1
]}

KONOPELSKI, JP ^{[1
]}

机构：

[1] UNIV CALIF SANTA CRUZ,DEPT CHEM & BIOCHEM,SANTA CRUZ,CA 95064

来源：

TETRAHEDRON | 1993年 / 49卷 / 41期

关键词：

D O I：

10.1016/0040-4020(93)80005-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure heterocycle 2 is deprotonated at C6 with tert-butyllithium at -78-degrees-C. The resulting carbanion reacts with alkyl halides and aldehydes to give the corresponding alkylated products. Reduction of the double bond followed by hydrolysis affords enantiomerically pure beta-alkyl-beta amino acids.

引用

页码：9183 / 9190

页数：8

共 45 条

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