MICHAELIS-MENTEN EQUATION FOR AN ENZYME IN AN OSCILLATING ELECTRIC-FIELD

被引：52

作者：

ROBERTSON, B

ASTUMIAN, RD

机构：

[1] National Institute of Standards and Technology, Gaithersburg, Maryland

来源：

BIOPHYSICAL JOURNAL | 1990年 / 58卷 / 04期

关键词：

D O I：

10.1016/S0006-3495(90)82441-3

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The electric charges on an enzyme may move concomitantly with a conformational change. Such an enzyme will absorb energy from an oscillating electric field. If in addition the enzyme has a larger association constant for substrate than for product, as is often true, it can use this energy to drive the catalyzed reaction away from equilibrium. Approximate analytical expressions are given for the field-driven flux, electrical power absorbed, free-energy produced per unit time, thermodynamic efficiency, and zero-flux concentrations. The field-driven flux is written as a generalized Michaelis-Menten equation. © 1990, The Biophysical Society. All rights reserved.

引用

页码：969 / 974

页数：6