ANTIMICROBIAL RESISTANCE OF PNEUMOCOCCI IN CHILDREN WITH ACUTE LOWER RESPIRATORY-TRACT INFECTION IN PAKISTAN

被引:112
作者
MASTRO, TD
GHAFOOR, A
NOMANI, NK
ISHAQ, Z
ANWAR, F
GRANOFF, DM
SPIKA, JS
THORNSBERRY, C
FACKLAM, RR
机构
[1] NATL INST HLTH,ISLAMABAD,PAKISTAN
[2] WASHINGTON UNIV,SCH MED,EDWARD MALLINCKRODT DEPT PEDIAT,DIV INFECT DIS,ST LOUIS,MO 63110
[3] CTR DIS CONTROL,CTR INFECT DIS,HOSP INFECT PROGRAM,ANTIMICROB INVEST BRANCH,ATLANTA,GA 30333
关键词
D O I
10.1016/0140-6736(91)90813-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
87 strains of Streptococcus pneumoniae isolated during three winter seasons (1986-89) from the blood of children with acute lower respiratory tract infection (ALRI) in Pakistan were serotyped and tested for susceptibility to a range of antimicrobial agents. 97% of isolates were resistant to at least one antimicrobial drug. 62% had decreased susceptibility to co-trimoxazole (trimethoprim/sulphamethoxazole) (31% were fully resistant) and 39% were resistant to chloramphenicol. All isolates were susceptible to erythromycin, cefaclor, cephalothin, ceftriaxone, cefuroxime, rifampicin, vancomycin, and clindamycin. 29% of isolates were neither vaccine types nor vaccine-related types. Serotype distribution and antimicrobial susceptibility varied significantly during the three winter seasons. No single serotype was found in all three winters. The findings highlight the need for surveillance of antimicrobial resistance and serotype distribution of S pneumoniae in developing countries as a guide both to the choice of agent for treatment of pneumococcal infections, especially ALRI, and to the formulation of new pneumococcal conjugate vaccines for use in young children.
引用
收藏
页码:156 / 159
页数:4
相关论文
共 34 条
[21]   CLINICAL SIGNS THAT PREDICT DEATH IN CHILDREN WITH SEVERE PNEUMONIA [J].
SHANN, F ;
BARKER, J ;
POORE, P .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1989, 8 (12) :852-855
[22]  
SHANN F, 1984, LANCET, V2, P537
[23]   ETIOLOGY OF SEVERE PNEUMONIA IN CHILDREN IN DEVELOPING-COUNTRIES [J].
SHANN, F .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1986, 5 (02) :247-252
[24]  
WALL RA, 1986, B WORLD HEALTH ORGAN, V64, P553
[25]  
WARD J, 1981, REV INFECT DIS, V3, P254
[26]  
WEINBERG GA, 1990, B WORLD HEALTH ORGAN, V68, P179
[27]   CLONAL ANALYSIS OF HEMOPHILUS-INFLUENZAE ISOLATED FROM CHILDREN FROM PAKISTAN WITH LOWER RESPIRATORY-TRACT INFECTIONS [J].
WEINBERG, GA ;
GHAFOOR, A ;
ISHAQ, Z ;
NOMANI, NK ;
KABEER, M ;
ANWAR, F ;
BURNEY, MI ;
QURESHI, AW ;
MUSSER, JM ;
SELANDER, RK ;
GRANOFF, DM .
JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (04) :634-643
[28]  
1986, WHORSD85
[29]  
1986, B WORLD HEALTH ORGAN, V64, P929
[30]  
1988, WHOARI893