AUTOMATED SYNTHESIS OF CYCLIC OLIGODEOXYRIBONUCLEOTIDES VIA PHOSPHORAMIDITE METHOD

被引：9

作者：

CONTE, MR

MAYOL, L

MONTESARCHIO, D

PICCIALLI, G

SANTACROCE, C

机构：

[1] UNIV NAPOLI FEDERICO II,DIPARTIMENTO CHIM ORGAN & BIOL,VIA MEZZOCANNONE 16,I-80134 NAPLES,ITALY

[2] UNIV NAPOLI FEDERICO II,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 3-4期

关键词：

D O I：

10.1080/07328319308017831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The functionalized polyethylene glycol/polystyrene copolymer support 4 was shown to be suitable for a completely automated synthesis of small- to medium-sized cyclic oligodeoxyribonucleotides. Syntheses of the linear precursors were achieved by the phosphoramidite method, whereas the cyclization reactions were based on the phosphotriester chemistry.

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页码：351 / 358

页数：8

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