QUANTITATIVE COMPARISON BETWEEN DIFFERENTIAL ADHESION MODELS AND CELL SORTING IN THE PRESENCE AND ABSENCE OF FLUCTUATIONS

被引：104

作者：

MOMBACH, JCM ^{[1
]}

GLAZIER, JA ^{[1
]}

RAPHAEL, RC ^{[1
]}

ZAJAC, M ^{[1
]}

机构：

[1] UNIV FED RIO GRANDE SUL,INST FIS,BR-91501970 PORTO ALEGRE,RS,BRAZIL

来源：

PHYSICAL REVIEW LETTERS | 1995年 / 75卷 / 11期

关键词：

D O I：

10.1103/PhysRevLett.75.2244

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We study the effect of inhibition of cell-membrane ruffling on cell sorting in experiments and simulations. We use aggregates of neural retinal and pigmented retinal cells obtained from chicken embryos and inhibit membrane ruffling by adding the drug cytochalasin B to the culture medium. Simulations using the large-Q Potts model with differential adhesivity, with the simulation temperature controlling the membrane ruffling amplitude, agree quantitatively with the experimental results for both normal and low fluctuation sorting, providing strong support for the validity of the model. In both cases, inhibition of ruffling prevents large scale cell sorting.

引用

页码：2244 / 2247

页数：4

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