MAPPING OF A QUANTITATIVE TRAIT LOCUS FOR BLOOD-PRESSURE ON RAT CHROMOSOME-2

被引：88

作者：

DENG, AY

DENE, H

RAPP, JP

机构：

[1] Dept. of Physiol. and Molec. Med., Medical College of Ohio, Toledo

[2] Dept. of Physiol. and Molec. Med., Health Science Building, Medical College of Ohio, Toledo, OH 43699

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1994年 / 94卷 / 01期

关键词：

DAHL SALT-SENSITIVE RAT; NA+; K+-ATPASE ALPHA-1; INTERVAL MAPPING; QUANTITATIVE TRAIT LOCUS; HYPERTENSION;

D O I：

10.1172/JCI117341

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F-2 populations of male rats raised on high salt (8% NaCl) diet from weaning were studied: F-2(WKY x S), derived from a cross of Dahl salt-sensitive rats(S) and Wistar-Kyoto rats (WKY); and F-2(MNS X S), derived from a cross of S rats and Milan normotensive strain (hZNS). In both populations a blood pressure QTL was localized between Na+,K+-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.

引用

页码：431 / 436

页数：6

共 39 条

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