CHEMILUMINESCENCE DETERMINATION OF CAPTOPRIL BASED ON A RHODAMINE-B SENSITIZED CERIUM(IV) METHOD

被引：117

作者：

ZHANG, XR

BAEYENS, WRG

VANDERWEKEN, G

CALOKERINOS, AC

NAKASHIMA, K

机构：

[1] SHAANXI NORMAL UNIV,DEPT CHEM,XIAN 710062,PEOPLES R CHINA

[2] UNIV ATHENS,DEPT CHEM,ANALYT CHEM LAB,GR-15771 ATHENS,GREECE

[3] NAGASAKI UNIV,SCH PHARMACEUT SCI,NAGASAKI 852,JAPAN

来源：

ANALYTICA CHIMICA ACTA | 1995年 / 303卷 / 01期

关键词：

CHEMILUMINESCENCE; CAPTOPRIL; CERIUM(IV); RHODAMINE B; PHARMACEUTICAL ANALYSIS;

D O I：

10.1016/0003-2670(94)00485-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new chemiluminescence method for the determination of captopril is described. The method is based on the chemiluminescence reaction of captopril with cerium(IV) in sulphuric acid medium. Rhodamine B is suggested as a fluorescing compound for the energy-transferred excitation. This sensitized-type of chemiluminescence emission allows quantitation of captopril concentrations in the 0.1-6.0 mu M range with a detection limit of 0.037 mu M original concentration. The experimental conditions for the reaction are optimized, the possible reaction mechanism is discussed and a direct application on a commercial drug formulation is given.

引用

页码：121 / 125

页数：5

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