INVITRO ACTIVITY OF MDL-62,879 (GE2270-A) AGAINST AEROBIC GRAM-POSITIVE AND ANAEROBIC-BACTERIA

被引：12

作者：

KING, A ^{[1
]}

BETHUNE, L ^{[1
]}

PHILLIPS, I ^{[1
]}

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, ST THOMAS HOSP, DEPT MICROBIOL, LONDON SE1 7EH, ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 04期

关键词：

D O I：

10.1128/AAC.37.4.746

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of common aerobic gram-positive and anaerobic organisms was determined. MDL 62,879 was highly active against staphylococci (MIC for 90% of isolates [MIC90], 0.125 mug/ml), streptococci (MIC90, 1 mug/ml), and enterococci (MIC90, 0.03 mug/ml). All isolates of peptostreptococci and Mobiluncus spp. were susceptible, as were most isolates of clostridia. MDL 62,879 was not active against isolates of fusobacteria or Bacteroides spp., but some isolates of Prevotella spp. and Porphyromonas asaccharolytica were susceptible.

引用

页码：746 / 749

页数：4

共 7 条

[1]

[Anonymous], 1991, J Antimicrob Chemother, V27 Suppl D, P1

[2] THE CAUSATIVE ORGANISMS OF SEPTICEMIA AND THEIR EPIDEMIOLOGY [J].