GLYCINE ANTAGONISTS BLOCK THE INDUCTION OF LONG-TERM POTENTIATION IN CA1 OF RAT HIPPOCAMPAL SLICES

被引：27

作者：

IZUMI, Y

CLIFFORD, DB

ZORUMSKI, CF

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 AUDUBON AVE,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT NEUROL,ST LOUIS,MO 63110

[3] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

关键词：

7-Chlorokynurenic acid; Cycloleucine; Glycine; Hippocampus; Long-term potentiation; N-Methyl-d-aspartate;

D O I：

10.1016/0304-3940(90)90212-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 μM) or 7-chlorokynurenic acid (1-5 μM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 μM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus. © 1990.

引用

页码：251 / 256

页数：6

共 17 条

[1] MK-801 BLOCKS NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION AND LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES [J].