ABNORMAL LUNG DEVELOPMENT AND CLEFT-PALATE IN MICE LACKING TGF-BETA-3 INDICATES DEFECTS OF EPITHELIAL-MESENCHYMAL INTERACTION

被引：883

作者：

KAARTINEN, V

VONCKEN, JW

SHULER, C

WARBURTON, D

BU, D

HEISTERKAMP, N

GROFFEN, J

机构：

[1] CHILDRENS HOSP LOS ANGELES,RES INST,DEPT SURG & PEDIAT 3,LOS ANGELES,CA 90027

[2] UNIV SO CALIF,SCH DENT,CTR CRANIOFACIAL MOLEC BIOL,LOS ANGELES,CA 90033

来源：

NATURE GENETICS | 1995年 / 11卷 / 04期

关键词：

D O I：

10.1038/ng1295-415

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A broad spectrum of biological activities has been proposed for transforming growth factor-beta 3 (TGF-beta 3). To study TGF-beta 3 function in development, TGF-beta 3 null mutant mice were generated by gene-targeting. Within 20 hours of birth, homozygous TGF-beta 3 -/- mice die with unique and consistent phenotypic features including delayed pulmonary development and defective palatogenesis. Unlike other null mutants with cleft palate, TGF-beta 3 -/- mice lack other concomitant craniofacial abnormalities. This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction.

引用

页码：415 / 421

页数：7

共 54 条

[31] EPITHELIAL MESENCHYMAL TRANSFORMATION OF EMBRYONIC CARDIAC ENDOTHELIAL-CELLS IS INHIBITED BY A MODIFIED ANTISENSE OLIGODEOXYNUCLEOTIDE TO TRANSFORMING GROWTH-FACTOR BETA-3 [J].