CYTOGENETIC FINDINGS IN A PRIMARY MALIGNANT FIBROUS HISTIOCYTOMA OF BONE AND THE LUNG METASTASIS

被引：16

作者：

BRIDGE, JA

SANGER, WG

NEFF, JR

HESS, MM

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT PEDIAT & PATHOL,OMAHA,NE 68105

[2] UNIV NEBRASKA,MED CTR,DEPT ORTHOPAED SURG,OMAHA,NE 68105

来源：

PATHOLOGY | 1990年 / 22卷 / 01期

关键词：

Cytogenetics; Double minutes; Homogeneously staining region; Malignant fibrous histiocytoma;

D O I：

10.3109/00313029009061420

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cytogenetic studies were performed on a malignant fibrous histiocytoma of bone and its metastasis to lung. Numerical chromosome abnormalities were described for all chromosomes except chromosomes 2, 4 and 16. Structural abnormalities in the primary tumor involved chromosomes 1, 3, 5,10,11, 13,15, 16 and 17. The chromosomal rearrangements seen both in the primary tumor and its metastasis involved chromosomes 13,15 and 17. Two X chromosomes contained large homogeneously staining regions (HSRs) in the primary tumor which were replaced by multiple double minutes (DMs) in the metastatic tumor. © 1990 Royal College of Pathologists of Australasia.

引用

页码：16 / 19

页数：4

共 21 条

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