MODIFIED TAXOLS .10. PREPARATION OF 7-DEOXYTAXOL, A HIGHLY BIOACTIVE TAXOL DERIVATIVE, AND INTERCONVERSION OF TAXOL AND 7-EPI-TAXOL

被引：68

作者：

CHAUDHARY, AG ^{[1
]}

RIMOLDI, JM ^{[1
]}

KINGSTON, DGI ^{[1
]}

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 15期

关键词：

D O I：

10.1021/jo00067a008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deoxygenation of taxol at C-7 can be achieved through its S-methyldithiocarboxy derivative 3 to yield a product which is more cytotoxic than-taxol to P-388 cells.

引用

页码：3798 / 3799

页数：2

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