MODIFIED TAXOLS .10. PREPARATION OF 7-DEOXYTAXOL, A HIGHLY BIOACTIVE TAXOL DERIVATIVE, AND INTERCONVERSION OF TAXOL AND 7-EPI-TAXOL

被引:68
作者
CHAUDHARY, AG [1 ]
RIMOLDI, JM [1 ]
KINGSTON, DGI [1 ]
机构
[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061
关键词
D O I
10.1021/jo00067a008
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Deoxygenation of taxol at C-7 can be achieved through its S-methyldithiocarboxy derivative 3 to yield a product which is more cytotoxic than-taxol to P-388 cells.
引用
收藏
页码:3798 / 3799
页数:2
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