GD-EOB-DTPA ENHANCEMENT PATTERN OF HEPATOCELLULAR CARCINOMAS IN RATS - COMPARISON WITH TC-99M-IDA UPTAKE

被引：16

作者：

VANBEERS, BE

GRANDIN, C

PAUWELS, S

MOTTET, I

GOUDEMANT, JF

DELOS, M

DEMEURE, R

PRINGOT, J

机构：

[1] UNIV CATHOLIQUE LOUVAIN,ST LUC UNIV HOSP,DEPT INTERNAL MED,B-1200 BRUSSELS,BELGIUM

[2] UNIV CATHOLIQUE LOUVAIN,ST LUC UNIV HOSP,DEPT PATHOL,B-1200 BRUSSELS,BELGIUM

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1994年 / 4卷 / 03期

关键词：

COMPARATIVE STUDIES; CONTRAST ENHANCEMENT; CONTRAST MEDIA; EXPERIMENTAL STUDIES; GADOLINIUM; LIVER NEOPLASMS; DIAGNOSIS;

D O I：

10.1002/jmri.1880040321

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The enhancement pattern of chemically induced hepatocellular carcinomas (HCCs) after intravenous administration on of the hepatobiliary magnetic resonance (MR) contrast agent gadolinium-EOB-DTPA (ethoxybenzyl-diethylenetriaminepentaacetic acid) was compared with the uptake pattern of technetium-99m-labeled iminodiacetic acid (IDA), a hepatobiliary radioactive tracer. The hepatocyte uptake of both the contrast agent and the scintigraphic agent has been shown to be driven by the organic anion transporter. The tumors enhanced less than the liver after Gd-EOB-DTPA administration, whereas the Tc-99m-IDA uptake of differentiated HCCs exceeded that of the liver at 30 minutes and 3 hours after administration. The enhancement pattern of a differentiated HCC with Gd-EOB-DTPA does not mirror that seen with Tc-99m-IDA.

引用

页码：351 / 354

页数：4

共 18 条

[1]

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