PROSTAGLANDIN-I2 AS A POTENTIATOR OF ACUTE-INFLAMMATION IN RATS

被引：57

作者：

KOMORIYA, K ^{[1
]}

OHMORI, H ^{[1
]}

AZUMA, A ^{[1
]}

KUROZUMI, S ^{[1
]}

HASHIMOTO, Y ^{[1
]}

机构：

[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19146

来源：

PROSTAGLANDINS | 1978年 / 15卷 / 04期

关键词：

carrageenin oedema; histamine; PGE[!sub]1[!/sub; PGI[!sub]2[!/sub; vascular permeability;

D O I：

10.1016/0090-6980(78)90052-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin I2 potentiated the paw swelling induced by carrageenin in rats. Prostaglandin I2 (0.1 μg) showed similar activity to PGE1 (0.01 μg). This potentiating property disappeared in 60 minutes and was completely abolished by diphenhydramine (25 mg kg-1, i.p.). In vascular permeability tests, PGI2 itself (2.5 × 10-10 mol, 88 ng) caused no dye leakage reaction, but PGE1 (2.5 × 10-10 mol, 88.5 ng) caused a significant dye leakage. This effect of PGE1 was statistically significant compared with vehicle- or PGI2-treated group (p<0.05). Prostaglandin I2 potentiated the increased vascular permeability induced by 5-hydroxytriptamine (2.5 × 10-10 mol), bradykinin (5 × 10-10 mol) and histamine (2 × 10-10 to 2 × 10-8 mol). The potentiation was the most evidence in the case of histamine. © 1978.

引用

页码：557 / 564

页数：8