INCREASE IN PLASMA NITRIC-OXIDE END-PRODUCTS FOLLOWING RAT CORTICAL INJURY

被引：12

作者：

YAMANAKA, K

KUMURA, E

IWATSUKI, K

YOSHIMINE, T

MASANA, Y

HAYAKAWA, T

SHIGA, T

KOSAKA, H

机构：

[1] OSAKA UNIV,SCH MED,DEPT NEUROSURG,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT PHYSIOL,SUITA,OSAKA 565,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 194卷 / 1-2期

关键词：

NITRIC OXIDE; NITRITE; NITRATE; CEREBRAL INJURY; AMINOGUANIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE;

D O I：

10.1016/0304-3940(95)11715-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The changes in plasma nitric oxide (NO) end products, nitrite (NO2-) and nitrate (NO3-), were studied following cortical injury in rats. At 3 days after stereotactic cortical injury (day 3), plasma NO end products were significantly increased (P < 0.01), and decreased by day 7. This increase on day 3 was inhibited by a selective inhibitor of inducible NO synthase (NOS), aminoguanidine (100 mg/kg, i.p. on days 1 and 2, P < 0.001). The present study first demonstrated the temporary increase in plasma NO end products, which is attributable to the inducible NOS activation after cerebral injury.

引用

页码：124 / 126

页数：3

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