SYNERGISTIC STIMULATION OF NITRIC-OXIDE HEMOGLOBIN PRODUCTION IN RATS BY RECOMBINANT INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR

被引：27

作者：

KOSAKA, H

HARADA, N

WATANABE, M

YOSHIHARA, H

KATSUKI, Y

SHIGA, T

机构：

[1] Department of Physiology, Medical School, Osaka University, Suita, Osaka, 565

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91571-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) is formed from arginine in Escherichia coli lipopolysaccharide (LPS) treated rat; however, none of specific cytokine inducing NO generation is yet determined. We studied the effect of interleukin 1 (IL-1) and tumor necrosis factor (TNF) on NO production in rats by detecting NO-hemoglobin in their blood, using electron spin resonance. Either IL-1 or TNF alone stimulated NO-hemoglobin formation. Combined administration of IL-1 and TNF markedly enhanced NO-hemoglobin generation, demonstrating the synergistic character of both stimuli on NO production. Further, LPS and TNF in combination were more potent stimulator of NO-hemoglobin production in rats than each alone. © 1992.

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页码：392 / 397

页数：6

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