MARKED NITROSATION BY STIMULATION WITH LIPOPOLYSACCHARIDE IN ASCORBIC ACID-DEFICIENT RATS

被引：31

作者：

KOSAKA, H

TSUDA, M

KURASHIMA, Y

ESUMI, H

TERADA, N

ITO, Y

UOZUMI, M

机构：

[1] NATL CANC CTR,RES INST,DIV BIOCHEM,CHUO KU,TOKYO 104,JAPAN

[2] CTR ADULT DIS,DEPT PATHOL,OSAKA 537,JAPAN

[3] OSAKA MED COLL,DEPT PATHOL,TAKATSUKI,OSAKA 569,JAPAN

[4] OSAKA PREFECTURAL INST PUBL HLTH,DIV ENVIRONM HLTH RES,HIGASHINARI KU,OSAKA 537,JAPAN

来源：

CARCINOGENESIS | 1990年 / 11卷 / 10期

关键词：

D O I：

10.1093/carcin/11.10.1887

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Marked formation of N-nitrosothioproline (N-nitroso-thiazolidine-4-carboxylic acid) by stimulation with Escherichia coli lipopolysaccharide (LPS) was demonstrated in ascorbic acid-deficient mutant rats (osteogenic disorder syndrome rats; ODS rats) unable to synthesize ascorbic acid. The amounts of urinary nitrate and N-nitrosothioproline excretion after thioproline administration was measured in ODS rats with and without ascorbic acid supplement before and after the injection of LPS. LPS caused marked increase of urinary nitrate excretion in both groups. Urinary N-nitrosothioproline excretion increased 6-fold after LPS injection in ODS rats not supplied with ascorbic acid, but supplement with ascorbic acid markedly decreased the excretion of N-nitroso-thioproline. © 1990 Oxford University Press.

引用

页码：1887 / 1889

页数：3

共 17 条

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