IMMUNOMODULATORY ACTION OF PROPOLIS .5. ANTICOMPLEMENTARY ACTIVITY OF A WATER-SOLUBLE DERIVATIVE

被引：21

作者：

IVANOVSKA, ND ^{[1
]}

DIMOV, VB ^{[1
]}

PAVLOVA, S ^{[1
]}

BANKOVA, VS ^{[1
]}

POPOV, SS ^{[1
]}

机构：

[1] BULGARIAN ACAD SCI,INST ORGAN CHEM,BU-1113 SOFIA,BULGARIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1995年 / 47卷 / 03期

关键词：

PROPOLIS; COMPLEMENT INHIBITION; WATER-SOLUBLE DERIVATIVE;

D O I：

10.1016/0378-8741(95)01273-G

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of a water-soluble derivative (WSD) of propolis on the classical pathway (CP) and the alternative (AP) complement activity has been investigated. The in vitro experiments show that WSD inhibits both pathways and the effect depends on the source of complement. The suppression of complement-mediated haemolysis proves to be time- and temperature-related. High WSD concentrations cause direct damage of the target erythrocytes. The estimation of C3-residual activity indicates that the preparation diminishes C3 functional activity.

引用

页码：135 / 143

页数：9