PROTEIN ENGINEERING OF SUBTILISIN BPN' - ENHANCED STABILIZATION THROUGH THE INTRODUCTION OF 2 CYSTEINES TO FORM A DISULFIDE BOND

被引:221
作者
PANTOLIANO, MW
LADNER, RC
BRYAN, PN
ROLLENCE, ML
WOOD, JF
POULOS, TL
机构
关键词
D O I
10.1021/bi00382a002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
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页码:2077 / 2082
页数:6
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共 33 条
[21]  
SCHELLMAN JOHN A., 1955, COMPT REND TRAV LAB CARLSBERG SER CHIM, V29, P223
[23]   THERMAL-DENATURATION OF STREPTOMYCES SUBTILISIN INHIBITOR, SUBTILISIN BPN', AND THE INHIBITOR-SUBTILISIN COMPLEX [J].
TAKAHASHI, K ;
STURTEVANT, JM .
BIOCHEMISTRY, 1981, 20 (21) :6185-6190
[24]  
Tanford C, 1970, Adv Protein Chem, V24, P1, DOI 10.1016/S0065-3233(08)60241-7
[25]   DISULFIDE BRIDGES IN GLOBULAR-PROTEINS [J].
THORNTON, JM .
JOURNAL OF MOLECULAR BIOLOGY, 1981, 151 (02) :261-287
[26]   AN INTRAMOLECULAR CROSS-LINKAGE OF LYSOZYME - FORMATION OF CROSS-LINKS BETWEEN LYSINE-1 AND HISTIDINE-15 WITH BIS(BROMOACETAMIDE) DERIVATIVES BY A 2-STAGE REACTION PROCEDURE AND PROPERTIES OF THE RESULTING DERIVATIVES [J].
UEDA, T ;
YAMADA, H ;
HIRATA, M ;
IMOTO, T .
BIOCHEMISTRY, 1985, 24 (22) :6316-6322
[27]   GENES FOR ALKALINE PROTEASE AND NEUTRAL PROTEASE FROM BACILLUS-AMYLOLIQUEFACIENS CONTAIN A LARGE OPEN READING FRAME BETWEEN THE REGIONS CODING FOR SIGNAL SEQUENCE AND MATURE PROTEIN [J].
VASANTHA, N ;
THOMPSON, LD ;
RHODES, C ;
BANNER, C ;
NAGLE, J ;
FILPULA, D .
JOURNAL OF BACTERIOLOGY, 1984, 159 (03) :811-819
[28]   DIRECTED MUTAGENESIS OF DIHYDROFOLATE-REDUCTASE [J].
VILLAFRANCA, JE ;
HOWELL, EE ;
VOET, DH ;
STROBEL, MS ;
OGDEN, RC ;
ABELSON, JN ;
KRAUT, J .
SCIENCE, 1983, 222 (4625) :782-788
[29]   ROLE OF BOUND CALCIUM-IONS IN THERMOSTABLE, PROTEOLYTIC-ENZYMES - SEPARATION OF INTRINSIC AND CALCIUM-ION CONTRIBUTIONS TO KINETIC THERMAL-STABILITY [J].
VOORDOUW, G ;
MILO, C ;
ROCHE, RS .
BIOCHEMISTRY, 1976, 15 (17) :3716-3724
[30]   THE 2-A RESOLUTION STRUCTURE OF A THERMOSTABLE RIBONUCLEASE-A CHEMICALLY CROSS-LINKED BETWEEN LYSINE RESIDUES-7 AND RESIDUES-41 [J].
WEBER, PC ;
SHERIFF, S ;
OHLENDORF, DH ;
FINZEL, BC ;
SALEMME, FR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8473-8477