EFFECT OF PROTEOGLYCANS ON HYDROXYAPATITE GROWTH IN-VITRO - THE ROLE OF HYALURONAN

被引:25
作者
PASCHALAKIS, P
VYNIOS, DH
TSIGANOS, CP
DALAS, E
MANIATIS, C
KOUTSOUKOS, PG
机构
[1] UNIV PATRAS, DEPT CHEM, BIOCHEM LAB, GR-26000 Patras, GREECE
[2] UNIV PATRAS, DEPT CHEM, PHYS CHEM LAB, GR-26000 Patras, GREECE
[3] UNIV PATRAS, DEPT CHEM ENGN, GR-26000 Patras, GREECE
关键词
AGGRECAN; PROTEOGLYCAN AGGREGATES; MINERALIZATION; HYDROXYAPATITE GROWTH;
D O I
10.1016/0304-4165(93)90006-T
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of cartilage proteoglycans on HA seed crystal growth was studied using a system providing constant supersaturation with respect to HA. The monomers were much less effective than the aggregates in reducing the rate of HA growth, which correlates with their affinity for the HA crystals. Hyaluronan, which is a normal constituent of the proteoglycan aggregates, behaved as a strong inhibitor of HA seed crystal growth and had an affinity constant similar to that of proteoglycan aggregates. The results indicate that inhibition of HA seed crystal growth is mediated through the interaction of hyaluronan with HA crystal surface and that the proteoglycans add to the volume of the adsorbate causing steric hindrance.
引用
收藏
页码:129 / 136
页数:8
相关论文
共 47 条
[31]   CHARACTERIZATION OF AGGREGATING PROTEOGLYCANS FROM THE PROLIFERATIVE, MATURING, HYPERTROPHIC, AND CALCIFYING ZONES OF THE CARTILAGINOUS PHYSIS [J].
MATSUI, Y ;
ALINI, M ;
WEBBER, C ;
POOLE, AR .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1991, 73A (07) :1064-1074
[32]   EFFECT OF HUMAN SALIVARY PROTEINS ON THE PRECIPITATION KINETICS OF CALCIUM-PHOSPHATE [J].
MORENO, EC ;
VARUGHESE, K ;
HAY, DI .
CALCIFIED TISSUE INTERNATIONAL, 1979, 28 (01) :7-16
[33]  
MURPHY J, 1962, ANAL CHIM ACTA, V26, P31
[34]   THE EXTRACELLULAR PROCESSING AND CATABOLISM OF HYALURONAN IN CULTURED ADULT ARTICULAR-CARTILAGE EXPLANTS [J].
NG, CK ;
HANDLEY, CJ ;
PRESTON, BN ;
ROBINSON, HC .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (01) :70-79
[35]   EXTENDED AND GLOBULAR PROTEIN DOMAINS IN CARTILAGE PROTEOGLYCANS [J].
PAULSSON, M ;
MORGELIN, M ;
WIEDEMANN, H ;
BEARDMOREGRAY, M ;
DUNHAM, D ;
HARDINGHAM, T ;
HEINEGARD, D ;
TIMPL, R ;
ENGEL, J .
BIOCHEMICAL JOURNAL, 1987, 245 (03) :763-772
[36]  
POOLE AR, 1989, ANAT REC, V224, P167
[37]   PERSISTENCE OF CARTILAGE PROTEOGLYCAN AND LINK PROTEIN DURING MATRIX-INDUCED ENDOCHONDRAL BONE-DEVELOPMENT - AN IMMUNOFLUORESCENT STUDY [J].
POOLE, AR ;
REDDI, AH ;
ROSENBERG, LC .
DEVELOPMENTAL BIOLOGY, 1982, 89 (02) :532-539
[38]   ROLE OF PROTEOGLYCANS IN ENDOCHONDRAL OSSIFICATION - IMMUNOFLUORESCENT LOCALIZATION OF LINK PROTEIN AND PROTEOGLYCAN MONOMER IN BOVINE FETAL EPIPHYSEAL GROWTH PLATE [J].
POOLE, AR ;
PIDOUX, I ;
ROSENBERG, L .
JOURNAL OF CELL BIOLOGY, 1982, 92 (02) :249-260
[39]   RELEASE OF HYALURONATE FROM EUKARYOTIC CELLS [J].
PREHM, P .
BIOCHEMICAL JOURNAL, 1990, 267 (01) :185-189
[40]  
SCHMID TM, 1982, J BIOL CHEM, V257, P2444