EFFECTS OF SHORT AND LONG-TERM ADMINISTRATION OF ACETYLSALICYLIC-ACID, ACETAMINOPHEN OR PHENACETIN ON DIET UTILIZATION IN RATS

被引：2

作者：

PRUDENCIO, MCR ^{[1
]}

RUIZROSO, B ^{[1
]}

DEMORA, C ^{[1
]}

VARELAMOREIRAS, G ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID, FAC FARM, DEPT NUTR 1, E-28040 MADRID, SPAIN

来源：

NUTRITION RESEARCH | 1994年 / 14卷 / 03期

关键词：

ACETAMINOPHEN; ACETYLSALICYLIC ACID; PHENACETIN; DIETARY PROTEIN; DIETARY METHIONINE DEFICIENCY; FAT DIGESTIBILITY;

D O I：

10.1016/S0271-5317(05)80178-2

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effects of short and long-term administration of acetylsalicylic acid, acetaminophen and phenacetin to rats on different nutritional parameters were investigated. Fat and protein digestibility, food and protein efficiency ratios as well as some hepatic parameters (liver weight, glutamic pyruvic transaminase and glutamic oxaloacetic transaminase activities) were determined. In addition, the effect of acetaminophen administration associated with a dietary methionine deficiency was also studied. Protein and fat digestibilities were unaffected by the drug treatments. Food efficiency ratio was significantly decreased (p < 0,05) either in acetylsalicylic acid or phenacetin-treated rats whereas the decrement was observed for acetaminophen only in case of cicutine with a methionine deficient diet. Protein efficiency ratio during the first two weeks of treatment was lower in the acetaminophen treated animals than the controls whereas in the acetaminophen methionine deficient diet protein efficiency ratio was decreased in the whole experimental period (6 weeks).

引用

页码：399 / 410

页数：12

共 35 条

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