APPROACHES TO THE DEVELOPMENT OF NOVEL ANTIHYPERTENSIVE DRUGS - CRUCIAL ROLE OF THE RENAL KALLIKREIN-KININ SYSTEM

被引：54

作者：

MAJIMA, M

KATORI, M

机构：

[1] Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, 228

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1995年 / 16卷 / 07期

关键词：

D O I：

10.1016/S0165-6147(00)89033-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The renal kallikrein-kinin system has been shown to be important in the development of hypertension, but its precise role remains to be determined. The recent use of mutant rats that are deficient in plasma kininogens and hence incapable of generating kinin in the renal tubules has facilitated elucidation of the involvement of kinin in hypertension. In this article, Masataka Majima and Makoto Katori provide evidence that the renal kallikrein-kinin system plays a crucial role in the development of hypertension and discuss a novel rationale for developing effective new antihypertensive drugs.

引用

页码：239 / 246

页数：8

共 34 条

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