INHALATION TOXICITY STUDIES ON CIGARETTE-SMOKE .2. TOBACCO-SMOKE INHALATION DOSIMETRY STUDIES ON SMALL LABORATORY-ANIMALS

被引：22

作者：

BINNS, R ^{[1
]}

BEVEN, JL ^{[1
]}

WILTON, LV ^{[1
]}

LUGTON, WGD ^{[1
]}

机构：

[1] BRITISH AMER TOBACCO CO LTD, CTR GRP RES & DEV, SOUTHAMPTON, HAMPSHIRE, ENGLAND

来源：

TOXICOLOGY | 1976年 / 6卷 / 02期

关键词：

D O I：

10.1016/0300-483X(76)90021-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A newly developed exposure system was used to carry out smoke dosimetry studies on rats, mice, hamsters and guinea pigs. In all species, smoke total particulate matter (TPM) deposited in significant amounts in the lower respiratory system (LRS) at dose levels ranging from 0.515-1.710 mg TPM/g respiratory tissue. Nasal deposition of smoke particulates occurred in all of the species examined. The significance of these dosimetry data in relation to the conduct of long-term comparative inhalation toxicity studies with tobacco smoke is discussed.

引用

页码：197 / 206

页数：10