GLUCOCORTICOID INDEPENDENT MEDIATION OF INTERLEUKIN-1 INDUCED CHANGES IN SERUM ZINC AND LIVER METALLOTHIONEIN LEVELS

被引：62

作者：

DISILVESTRO, RA

COUSINS, RJ

机构：

来源：

LIFE SCIENCES | 1984年 / 35卷 / 21期

关键词：

D O I：

10.1016/0024-3205(84)90510-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Interleukin 1 (IL-1) causes changes in Zn metabolism which was attributed to mediation, at least in part, by glucocorticoids. IL-1 actually lowered serum corticosterone levels in rats. Adrenalectomy only partially inhibited the ability of IL-1 to depress serum Zn levels and increase the amoung of Zn associated with hepatic metallothionein. IL-1 increased total liver metallothionein protein to similar levels in both adrenalectomized and normal rats. Administering the synthetic glucocorticoid dexamethasone with IL-1 to adrenalectomized rats produced additive, but not synergistic effects on serum Zn and metallothionein concentrations. Studies with actinomycin D suggested that IL-1 induction of metallothionein might involve glucagon.

引用

页码：2113 / 2118

页数：6

共 26 条

[1]

COUSINS RJ, PHYSL REV

[2] INTERLEUKIN-1 [J].