REDOX SIGNALING AND THE CONTROL OF CELL-GROWTH AND DEATH

被引：209

作者：

POWIS, G ^{[1
]}

BRIEHL, M ^{[1
]}

OBLONG, J ^{[1
]}

机构：

[1] UNIV ARIZONA, DEPT PATHOL, TUCSON, AZ 85724 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 1995年 / 68卷 / 01期

关键词：

REDOX SIGNALING; CELL GROWTH; THIOREDOXIN; GLUTAREDOXIN; GLUTATHIONE; TRANSCRIPTION FACTORS;

D O I：

10.1016/0163-7258(95)02004-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cells maintain a reduced intracellular state in the face of a highly oxidizing extracellular environment. Redox signalling pathways provide a link between external stimuli, through the flavoenzyme-mediated NADPH-dependent reduction of intracellular peptide thiols, such as glutathione, thioredoxin, glutaredoxin, and redox factor-1, to the posttranslational redox modification of certain intracellular proteins. This can affect the proteins' correct folding, assembly into multimeric complexes, enzymatic activity, and their binding as transcription factors to specific DNA sequences. Such changes have been linked to altered cell growth and death.

引用

页码：149 / 173

页数：25

共 224 条

[21] THE PURIFICATION OF EARLY-PREGNANCY FACTOR TO HOMOGENEITY FROM HUMAN PLATELETS AND IDENTIFICATION AS CHAPERONIN-10 [J].