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PHARMACOLOGICAL MODULATORS OF THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR

被引：41
作者：
MICHELANGELI, F
MEZNA, M
TOVEY, S
SAYERS, LG
机构：
[1] School of Biochemistry, University of Birmingham, Edgbaston, Birmingham
来源：
NEUROPHARMACOLOGY | 1995年 / 34卷 / 09期
关键词：
INOSITOL TRISPHOSPHATE RECEPTOR; INSP(3)-INDUCED CA2+ RELEASE; CA2+ MOBILIZATION; ANTAGONISTS;
D O I：
10.1016/0028-3908(95)00053-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Elevation of cytosolic calcium concentrations, induced by many neurotransmitters, plays a crucial role in, neuronal function. Some neurotransmitters produce the second messenger InsP(3) which activates an intracellular calcium channel (InsP(3) receptor) usually located in the endoplasmic reticulum. This article undertakes a comprehensive survey of most pharmacological modulators of the InsP(3) receptor so far reported. This review discusses in detail competitive antagonists, non-competitive antagonists and thiol reactive reagents, highlighting their modes of action and in some cases indicating drawbacks in their use.
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页码：1111 / 1122
页数：12
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