PHARMACOLOGICAL MODULATORS OF THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR

被引：41

作者：

MICHELANGELI, F

MEZNA, M

TOVEY, S

SAYERS, LG

机构：

[1] School of Biochemistry, University of Birmingham, Edgbaston, Birmingham

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 09期

关键词：

INOSITOL TRISPHOSPHATE RECEPTOR; INSP(3)-INDUCED CA2+ RELEASE; CA2+ MOBILIZATION; ANTAGONISTS;

D O I：

10.1016/0028-3908(95)00053-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Elevation of cytosolic calcium concentrations, induced by many neurotransmitters, plays a crucial role in, neuronal function. Some neurotransmitters produce the second messenger InsP(3) which activates an intracellular calcium channel (InsP(3) receptor) usually located in the endoplasmic reticulum. This article undertakes a comprehensive survey of most pharmacological modulators of the InsP(3) receptor so far reported. This review discusses in detail competitive antagonists, non-competitive antagonists and thiol reactive reagents, highlighting their modes of action and in some cases indicating drawbacks in their use.

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页码：1111 / 1122

页数：12

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