RELEASE-ENHANCING GLYCINE-DEPENDENT PRESYNAPTIC NMDA RECEPTORS EXIST ON NORADRENERGIC TERMINALS OF HIPPOCAMPUS

被引：113

作者：

PITTALUGA, A ^{[1
]}

RAITERI, M ^{[1
]}

机构：

[1] UNIV GENOA,IST FARMACOL & FARMACOGNOSIA,VIALE CEMBRANO 4,I-16148 GENOA,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 02期

关键词：

Glycine; Hippocampus (rat); NMDA (N-methyl-D-aspartate); Noradrenaline release; Synaptosomes (superfused);

D O I：

10.1016/0014-2999(90)94153-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The release of [3H]noradrenaline ([3H]NA) in superfused rat hippocampal synaptosomes was increased concentration dependently by N-methyl-D-aspartate (NMDA). Glycine (1 μM), ineffective on its own, doubled the efficacy of NMDA with no significant change in affinity. The effects of NMDA alone and those of NMDA + glycine were antagonized by D-2-amino-5-phosphonopentanoate (D-AP5), Mg2+, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohept-5, 10-imine hydrogen maleate (MK-801) or 7-chloro-kynurenate (7-Cl-KYNA) but not by strychnine. The data provide a direct demonstration of the existence of presynaptic NMDA receptors. © 1990.

引用

页码：231 / 234

页数：4

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