PHONEUTRIA-NIGRIVENTER (ARMED SPIDER) VENOM INDUCES INCREASED VASCULAR-PERMEABILITY IN RAT AND RABBIT SKIN INVIVO

被引：40

作者：

ANTUNES, E ^{[1
]}

MARANGONI, RA ^{[1
]}

BRAIN, SD ^{[1
]}

DENUCCI, G ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL, DIV BIOSCI, PHARMACOL GRP, LONDON WC2R 2LS, ENGLAND

来源：

TOXICON | 1992年 / 30卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/0041-0101(92)90045-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of intradermally injected Phoneutria nigriventer venom (PNV) on vascular permeability of both rat and rabbit skin has been investigated. Oedema formation was measured as the local extravascular accumulation at skin sites of intravenously injected I-125-human serum albumin. In both rat and rabbit PNV induced dose-dependent oedema which was greatly potentiated by the vasodilators calcitonin-gene-related peptide and prostaglandin E1. In rats, PNV-induced oedema was markedly reduced either by previous treatment of the animals with the histamine H-1 antagonist mepyramine and the serotonin antagonist methysergide or when venom was dialysed, indicating a major role for histamine and serotonin. In rabbits, dialysis of the venom to remove histamine and serotonin did not reduce PNV-induced oedema, indicating presence of oedematogenic component(s) which are different from the amines histamine or serotonin.

引用

页码：1011 / 1016

页数：6