NC-1300, A PROTON-PUMP INHIBITOR, REQUIRES GASTRIC-ACID TO EXERT CYTOPROTECTION IN RAT GASTRIC-MUCOSA

被引：5

作者：

ARAKAWA, T

FUKUDA, T

HIGUCHI, K

KOIKE, K

SATOH, H

KOBAYASHI, K

机构：

[1] Third Department of Internal Medicine, Osaka City University Medical School, Osaka 545, 1-5-7 Asahimachi, Abeno-ku

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1993年 / 61卷 / 04期

关键词：

PROTON-PUMP INHIBITOR; CYTOPROTECTION; GASTRIC MUCOSA; ETHANOL DAMAGE;

D O I：

10.1254/jjp.61.299

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effect of gastric acid suppression on the cytoprotective effect of a single dose of NC-1300 given intragastrically was studied. NC-1300 given intragastrically prevented gastric mucosal damage caused by absolute ethanol in rats in a dose-related manner, while the drug given subcutaneously did not. Pretreatment with NC-1300 given subcutaneously to suppress acid secretion abolished the protective effect of NC-1300 given intragastrically, but not in the presence of 0.1 N HCl. Repeated intragastric administration of NC-1300 for 7 days failed to prevent the ethanol damage. These results suggest that NC-1300 requires gastric acid to exert a protective effect against ethanol in rat gastric mucosa.

引用

页码：299 / 302

页数：4

共 8 条

[1] EFFECTS OF ZINC L-CARNOSINE ON GASTRIC-MUCOSAL AND CELL-DAMAGE CAUSED BY ETHANOL IN RATS - CORRELATION WITH ENDOGENOUS PROSTAGLANDIN-E2 [J].

ARAKAWA, T ;

SATOH, H ;

NAKAMURA, A ;

NEBIKI, H ;

FUKUDA, T ;

SAKUMA, H ;

NAKAMURA, H ;

ISHIKAWA, M ;

SEIKI, M ;

KOBAYASHI, K .

DIGESTIVE DISEASES AND SCIENCES, 1990, 35 (05) :559-566

[2] PROTECTIVE ACTION OF OMEPRAZOLE, A BENZIMIDAZOLE DERIVATIVE, ON GASTRIC-MUCOSAL DAMAGE BY ASPIRIN AND ETHANOL IN RATS [J].

KONTUREK, SJ ;

BRZOZOWSKI, T ;

RADECKI, T .

DIGESTION, 1983, 27 (03) :159-164

[3]

LACY ER, 1982, GASTROENTEROLOGY, V83, P619

[4] OMEPRAZOLE PROVIDES PROTECTION AGAINST EXPERIMENTALLY INDUCED GASTRIC-MUCOSAL LESIONS [J].

MATTSSON, H ;

ANDERSSON, K ;

LARSSON, H .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 91 (01) :111-114

[5] CYTOPROTECTIVE EFFECTS OF NC-1300 AND OMEPRAZOLE ON HCL-ETHANOL-INDUCED GASTRIC-LESIONS IN RATS [J].

OKABE, S ;

MIYAKE, H ;

AWANE, Y .

JAPANESE JOURNAL OF PHARMACOLOGY, 1986, 42 (01) :123-133

[6] EFFECTS OF NC-1300 AND ITS DEGRADATION PRODUCTS ON GASTRIC-SECRETION AND HCL.ETHANOL-INDUCED GASTRIC-LESIONS IN RATS [J].

OKABE, S ;

AKIMOTO, Y ;

MIYAKE, H ;

IMADA, J .

JAPANESE JOURNAL OF PHARMACOLOGY, 1987, 44 (01) :7-14

[7] MILD IRRITANTS PREVENT GASTRIC NECROSIS THROUGH ADAPTIVE CYTOPROTECTION MEDIATED BY PROSTAGLANDINS [J].

ROBERT, A ;

NEZAMIS, JE ;

LANCASTER, C ;

DAVIS, JP ;

FIELD, SO ;

HANCHAR, AJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (01) :G113-G121

[8]

SATOH H, 1989, J PHARMACOL EXP THER, V248, P806

← 1 →