THE FIRST SYNTHESIS OF THE NOVEL 2,8-DIOXABICYCLO[3.2.1]OCTANE RING-SYSTEM - A KEY FEATURE OF THE SQUALESTATINS

被引：25

作者：

AGGARWAL, VK

WANG, MF

ZAPARUCHA, A

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 01期

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D O I：

10.1039/c39940000087

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The lithium enolate of the acetonide of (S,S)-dimethyl tartrate 5 was prepared by treatment with lithium diisopropylamide in the presence of 12-crown-4, and added to acetonylacetone 6; reaction of the product with acid gave a mixture of cyclised adducts from which a single diastereoisomer was isolated and shown to have a structure consistent with the core of squalestatin.

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页码：87 / 88

页数：2

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