THE ISOLATION AND STRUCTURE ELUCIDATION OF ZARAGOZIC ACID-C, A NOVEL POTENT SQUALENE SYNTHASE INHIBITOR

被引：58

作者：

DUFRESNE, C

WILSON, KE

ZINK, D

SMITH, J

BERGSTROM, JD

KURTZ, M

REW, D

NALLIN, M

JENKINS, R

BARTIZAL, K

TRAINOR, C

BILLS, G

MEINZ, M

HUANG, LY

ONISHI, J

MILLIGAN, J

MOJENA, M

PELAEZ, F

机构：

[1] Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON | 1992年 / 48卷 / 47期

关键词：

D O I：

10.1016/S0040-4020(01)88327-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel zaragozic acid C (1) has been isolated as a potent inhibitor of squalene synthase. It was found to be a competitive inhibitor of rat lover squalene synthase with an apparent K(i) of 45 +/- 15 pM, and a broad spectrum antifungal agent against both yeast and filamentous fungi.

引用

页码：10221 / 10226

页数：6

共 13 条

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