SYNTHESIS OF FLUOROVINYLSALICYLIC ACIDS AND THEIR DERIVATIVES

被引：20

作者：

FILLER, R

LIN, S

ZHANG, ZX

机构：

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1995年 / 74卷 / 01期

关键词：

FLUOROVINYLSALICYLIC ACIDS; WITTIG REACTION; BENZOFURAN;

D O I：

10.1016/0022-1139(95)03255-C

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Palladium-catalyzed cross-coupling of iodosalicylic acid derivatives with polfluorovinyl zinc reagents provided the corresponding fluorovinyl-substituted salicylates. Methyl-5-(beta,beta)-difluorovinyl methyl salicylate was prepared by a Wittig reaction of the 5-formyl compound with the strongly nucleophilic ylide, [(Et(2)N)(3)P-CF2]. In one sequence, a fluorine-free benzofuran was obtained, instead of a difluorovinyl-salicylate.

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页码：69 / 75

页数：7

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