OVERPRODUCTION OF PROTEIN P53 CONTRIBUTES TO SIMIAN-VIRUS 40-MEDIATED TRANSFORMATION

被引：56

作者：

MICHALOVITZ, D ^{[1
]}

ELIYAHU, D ^{[1
]}

OREN, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT CHEM IMMUNOL, IL-76100 REHOVOT, ISRAEL

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1986年 / 6卷 / 10期

关键词：

D O I：

10.1128/MCB.6.10.3531

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible involvement of p53 overproduction in simian virus 40 (SV40) mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced to- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.

引用

页码：3531 / 3536

页数：6

共 40 条

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