GALACTOCEREBROSIDES ARE ANTIGENS FOR IMMUNOGLOBULINS IN SERA OF AN EXPERIMENTAL-MODEL OF TRYPANOSOMIASIS IN SHEEP

被引：14

作者：

JAUBERTEAU, MO

BENYOUNESCHENNOUFI, A

AMEVIGBE, M

BOUTEILLE, B

DUMAS, M

BRETON, JC

BAUMANN, N

机构：

[1] UNIV HOSP SALPETRIERE,INSERM,U134,47 BD HOP,F-75651 PARIS,FRANCE

[2] UNIV HOSP LIMOGES,DEPT NEUROL,LIMOGES,FRANCE

[3] UNIV HOSP LIMOGES,INST TROP NEUROL,LIMOGES,FRANCE

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1991年 / 101卷 / 01期

关键词：

GALACTOCEREBROSIDES; ANTIBODIES; AFRICAN TRYPANOSOMIASIS; AFRICAN TRYPANOSOMIASIS; MONOCLONAL-ANTIBODY; COMMON ANTIGENS; NERVOUS-SYSTEM; CRUZI; IGM; GANGLIOSIDES; NEUROPATHY; NEURONS; GLYCOSPHINGOLIPIDS;

D O I：

10.1016/0022-510X(91)90020-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In an experimental model of human African trypanosomiasis in sheep inoculated with Trypanosoma brucei brucei, we report an immunoglobulin reactivity towards central nervous system (CNS) glycolipids. Immunocharacterization of the glycolipid antigens was performed on thin-layer chromatography using peroxidase-labelled second antibody. An immunoreactivity against galactocerebroside antigens was observed in inoculated animals up to a dilution of 1:600 and was suppressed after immunoadsorption of sera on pure galactocerebrosides. As galactocerebroside antigen is responsible for demyelination in several experimental models, the relation between the important glycolipid immunoreactivity in inoculated sheep sera and the pathogenesis of CNS demyelination in African trypanosomiasis is suggested.

引用

页码：82 / 86

页数：5

共 36 条

[21] IGM IN A HUMAN NEUROPATHY RELATED TO PARAPROTEINEMIA BINDS TO A CARBOHYDRATE DETERMINANT IN THE MYELIN-ASSOCIATED GLYCOPROTEIN AND TO A GANGLIOSIDE [J].