HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR DIRECT SEPARATION OF 5-(PARA-HYDROXYPHENYL)-5-PHENYLHYDANTOIN ENANTIOMERS USING A CHIRAL TRIS(4-METHYLBENZOATE) COLUMN

被引：18

作者：

ETO, S

NODA, H

NODA, A

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT HOSP PHARM,1-1 ISEIGAOKA,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

[2] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 568卷 / 01期

关键词：

D O I：

10.1016/0378-4347(91)80349-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

After simple purification of the incubation mixture of phenytoin in isolated rat hepatocytes, 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH), which formed as a major metabolite, was readily resolved to each enantiomer by direct high-performance liquid chromatography on a cellulose tris(4-methylbenzoate) column, with a mobile phase of ethanol-water. It was also observed that the formation of S-(-)-p-HPPH was dominant, and the S/R ratio was 11.5.

引用

页码：157 / 163

页数：7

共 11 条

[1] BUTLER TC, 1957, J PHARMACOL EXP THER, V119, P1
[2] DAICEL, COMMUNICATION
[3] ETO S, UNPUB CHEM PHARM B
[4] FRITZ S, 1987, J PHARMACOL EXP THER, V241, P615
[5] DIRECT ENANTIOMERIC SEPARATION OF BETAXOLOL WITH APPLICATIONS TO ANALYSIS OF BULK DRUG AND BIOLOGICAL SAMPLES
KRSTULOVIC, AM
FOUCHET, MH
BURKE, JT
GILLET, G
DURAND, A
[J]. JOURNAL OF CHROMATOGRAPHY, 1988, 452 : 477 - 483
[6] MCCLANAHAN JS, 1986, J CHROMATOGR, V381, P438
[7] Moldeus P, 1978, Methods Enzymol, V52, P60
[8] OPTICAL RESOLUTION OF RACEMIC DRUGS BY CHIRAL HPLC ON CELLULOSE AND AMYLOSE TRIS(PHENYLCARBAMATE) DERIVATIVES
OKAMOTO, Y
ABURATANI, R
HATANO, K
HATADA, K
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1988, 11 (9-10): : 2147 - 2163
[9] ABSOLUTE-CONFIGURATION OF MAJOR METABOLITE OF 5,5-DIPHENYLHYDANTOIN, 5-(4'-HYDROXYPHENYL)-5-PHENYLHYDANTOIN
POUPAERT, JH
CAVALIER, R
CLAESEN, MH
DUMONT, PA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (12) : 1268 - 1271
[10] DIRECT ENANTIOMERIC SEPARATION OF SATERINONE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
RUDOLPH, M
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 525 (01): : 161 - 168

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