THE EFFECT OF WEIGHT CORRECTION ON RISK CALCULATIONS FOR DOWNS-SYNDROME SCREENING

被引：25

作者：

REYNOLDS, TM ^{[1
]}

PENNEY, MD ^{[1
]}

HUGHES, H ^{[1
]}

JOHN, R ^{[1
]}

机构：

[1] ROYAL GWENT HOSP,DEPT CHEM PATHOL,NEWPORT NPT-2VB,GWENT,WALES

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1991年 / 28卷

关键词：

ANTENATAL DIAGNOSIS; ALPHA FETOPROTEIN; HUMAN CHORIONIC GONADOTROPIN; UNCONJUGATED ESTRIOL;

D O I：

10.1177/000456329102800308

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Recent advances in prenatal screening have led to the possibility that the risk of Down's syndrome associated pregnancy may be assessed by blood tests for maternal serum alphafetoprotein, human chorionic gonadotrophin (and possibly unconjugated oestriol) taken at 15-18 weeks of gestation. In neural tube defect screening correction of maternal serum alphafetoprotein for maternal weight has been recommended, although the precise method for weight correction is still under debate. We report an assessment of weight correction for maternal serum alphafetoprotein and human chorionic gonadotrophin based on 1408 singleton pregnancies and for unconjugated oestriol based on 197 singleton pregnancies. We demonstrate that weight correction of maternal serum alphafetoprotein and human chorionic gonadotrophin is statistically valid but that correction of unconjugated oestriol is not.

引用

页码：245 / 249

页数：5

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