A SIMPLE SYNTHESIS OF C-GLUCOSIDES RELATED TO THE ANTITUMOR AGENT ETOPOSIDE

被引：7

作者：

ALLEVI, P

ANASTASIA, M

CIUFFREDA, P

SCALA, A

机构：

[1] Department of Chemistry and Biochemistry, University of Milan, I-20133 Milan

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1993年 / 12卷 / 02期

关键词：

D O I：

10.1080/07328309308021271

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of four new lignan derivatives 2a, 2b, 3a and 3b related to the anticancer agent etoposide has been accomplished. In these compounds a methylene or ethylene group of a C-glucoside separates the glucosidic moiety as present in etoposide (1) from its lignan aglycone bonded by an ethereal function. The key step in the synthesis involves the reaction of a benzylated alditol 4 or 5 and the unprotected 4'-demethylepipodophyllotoxin (6).

引用

页码：209 / 222

页数：14

共 22 条

[21] RAPID CHROMATOGRAPHIC TECHNIQUE FOR PREPARATIVE SEPARATIONS WITH MODERATE RESOLUTION [J].