PAIN MECHANISMS IN NEUROPATHY

被引:48
作者
OCHOA, JL
机构
[1] Good Samaritan Hosp Medical Center, Oregon Health Sciences University, Portland, OR 97210
关键词
D O I
10.1097/00019052-199410000-00008
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Current opinion on ''neuropathic'' pain is chaotic and divided. This review is a summary attempt at describing the principal hypotheses that are currently entertained and at interpreting the basic underlying mechanisms of these pains. Rather than relying preferentially on rigorous data generated from neurophysiological animal experimentation, reasonable priority is given to evidence derived from rigorous neurophysiological and psychophysical studies in human volunteers and patients. Issues such as the concept of ''centralization'' of neuropathic pain mechanisms, which dwell excessively upon extrapolation from animal experiment to human clinical reality, are highlighted as questionable. Psychogenic pseudoneuropathy, an entity of high clinical prevalence and low appreciation by basic scientists and the reflex sympathetic dystrophy establishment, is also given the emphasis it deserves.
引用
收藏
页码:407 / 414
页数:8
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