ENZYMATIC-SYNTHESIS OF NOVEL PHOSPHATIDYLGENIPIN, AND ITS ENHANCED CYTOTOXICITY

被引：16

作者：

TAKAMI, M ^{[1
]}

SUZUKI, Y ^{[1
]}

机构：

[1] OKAYAMA UNIV, BIORESOURCES RES INST, KURASHIKI, OKAYAMA 710, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 10期

关键词：

D O I：

10.1271/bbb.58.1897

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new phosphatidyl derivative, 1,2-dipalmitoyl-3-sn-phosphatidylgenipin (DPP-genipin), was found to be synthesized by the transfer reaction of a dipalmitoylphosphatidyl residue from 1,2-dipalmitoyl-3-sn-phosphatidylcholine (DPPC) to genipin by phospholipase D (PLD) from Streptomyces sp. in a biphasic system. DPP-genipin also transferred its phosphatidyl residue to choline by PLD, to reproduce DPPC and liberate genipin. DPP-genipin showed 6 to 52 times stronger cytotoxity than genipin to Hela cells, human embryonic lung fibroblasts (HEL), and MT-4 cells.

引用

页码：1897 / 1898

页数：2

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